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KMID : 0356919950290040477
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Korean Journal of Anesthesiology
1995 Volume.29 No. 4 p.477 ~ p.483
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Effect of Thiopental or Midazolam, Alone and in Combination, on the Induction Time and the Cardiovacular Responeses
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Abstract
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There was a report that midazolam-thiopental coinduction reduced ED99 of thiopental for hypnosis from 5.75 mg to 2.37 mg. This study was designed to test whether the former study can be used clinically and to compare midazolam-thiopental
coinduction
with thiopental or midazolam induction. After 120patients of ASA calssⅠ,Ⅱclassified into 3 groups randomly, 5.75 mg/kg of thiopental was injected intravenously to each patient for Group I while 0.23 mg/kg of midazolam was injected intravenously
to
each patient for GroupⅡ. For GroupⅢ, 2.37 mg/kg of thiopental was injected intrayenously to each patient one minute after 0.02 mg/kg of midazolam was injected. Induction rate, induction time, and the changes of cardiovascular response for each
group
have been compared and the results are as follows: 1) Induction rate was 100%, 75%, 75% for each group. 2) Time for the spontaneous eye closure and loss of the eyelid reflex for GroupⅠwere 12.2±8.0 seconds, 20.3±6.9 seconds respectively, while
for
Group Ⅱ51.5±26.5 seconds, 69.3±29.5 seconds, and for GroupⅢ, 25.3±7.4 seconds, 37.0±10.8 seconds (G. Ⅰbetween
groups statistically 4) It was also impossible to prove that the changes of blood pressure were more stable in one group than others statistically.
By judging from the results above, midazolam-pentothal coinduction can be a useful means of induction but coinduction is not superior to thiopental or midazolam induction. (Korean J Anesthesiol 1995; 29: 477∼483)
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